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Role of Vitamin B12 in the Body Vitamin B12 helps make red blood cells that carry oxygen

That selectivity is part of why it draws interest

Clinical trials and meta-analyses consistently show that DPP-4 inhibitors produce a modest but clinically meaningful reduction in HbA1c , typically in the range of: 0.5% to 1.0% (approximately 5.5 to 11 mmol/mol) when used as monotherapy or add-on therapy Reductions at the higher end of this range are more likely when baseline HbA1c is significantly elevated For example, sitagliptin has demonstrated reductions of around 0.60.8% in randomised controlled trials, while vildagliptin and saxagliptin show broadly comparable efficacy

Because it slows gastric emptying, it may worsen gastrointestinal conditions

and the table below that shows the surplus (or deficit) for all 55 countries modelled