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However, the baseline GLP-1 sensitivity was not exactly evaluated because the baseline hyperglycemic clamp was performed 2 to 7 days after treatment initiation [37]

Dr John Eng and his colleagues discovered a peptide in the venom called exendin-4 , which shared structural similarities with human GLP-1 but possessed a crucial advantage: it was resistant to breakdown by DPP-4

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Some published studies have pointed out that while such drugs help patients lose weight, there is a risk of loss of muscle mass