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Eng identified exendin-4 and published the finding in 1992

Unlike white fat, which stores energy, brown fat burns energy to generate heat, making its activation by Lean Drops a highly desirable outcome for metabolic optimization

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The fatty acid is first activated by addition of a CoA (forming acyl-CoA), then CPTI adds carnitine

It is engineered with two structural modifications relative to the 70-residue native protein: a substitution of arginine for glutamic acid at the third position and a 13-amino-acid extension at the N-terminus, giving a total length of 83 amino acids