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While there were many epigenetic changes associated with vitamin B 12 supplementation, trimethylated histone H3 Lys 36 (H3K36me3) was the histone modification that increased the most, and the only one that increased at both day 3 and day 10 of OSKM induction in MEFs (Extended Data Fig

Step 6: Mix gently Remove the syringe after injecting the BAC water

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