Two of the cases involved specific circumstances that make it hard to say tirzepatide was definitively the only cause: A medication switch gone wrong: A 59-year-old with type 2 diabetes developed acute pancreatitis two days after their provider switched them from 1 mg semaglutide to a 7.5 mg dose of tirzepatide, skipping the recommended low starting dose entirely
AstraZeneca discontinued these three formulations in the US in recent years, but generic Byetta was approved by the FDA in late 2024
Plaintiffs in the Ozempic lawsuit allege that semaglutide-based drugs, including Ozempic, caused serious gastrointestinal injuries such as gastroparesis, intestinal obstruction, and prolonged vomiting
Dietary fiber and polyphenols Fiber-rich foods like oats, legumes, bananas, onions, and garlic nourish SCFA-producing bacteria that can trigger GLP-1 release
Loss of Appetite : While appetite suppression is a desired effect, it may also be accompanied by a general decrease in food cravings
Novos Q1 2024 earnings cited ~6.5M monthly scripts, consistent with that run-rate (source)