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The root/shoot fresh weight ratio showed a slight decrease in ALA-treated plants compared to the control, suggesting that ALA relatively improved the growth of root system, which is directly impacted by the toxic Pb ions in the soil

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The anemia is presumed immune-mediated as it responds to immunosuppressive therapy, such as a combination of azathioprine in dogs (which can suppress the bone marrow in some dogs), cyclosporine (dogs and cats), mycophenolate and high doses of prednisolone (dogs and cats)

Some animal studies have even shown hormonal changes and ovarian stress after long-term use