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Simultaneously, MAPKs (p38, JNK, ERK) and NF-B are overactivated by excessive ROS, promoting inflammatory cytokine release and NLRP3 inflammasome activation, forming a vicious OSinflammationtissue injury cycle (97, 101)

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These side effects are often temporary and subside as the body adjusts to the supplement

Itchiness: Patients can experience annoying skin sensation and persistent urge to scratch on treatment site

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