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The expression of parathyroid hormone-related protein (PTHrP), which controls chondrocyte maturation during endochondral ossification, was enhanced in both articular cartilage and hypertrophic growth plate following selenium deficiency

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Following this, the receptors were then embedded in a rectangular 126 x 126 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphocholine (POPC) bilayer (previously built by using the VMD Membrane Builder plugin 1.1 at considering the coordinates retrieved from the OPM database to gain the correct orientation within the membrane, while removing the lipid molecules overlapping the receptor TMD bundle