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Data availability The RNA-seq data generated in this study are available on the National Center for Biotechnology Information (NCBI) database with SRA accession code: PRJNA1212571

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Being both water and fat-soluble means that ALA is widely distributed in plants and animals in both cellular membranes and in the cytosol (Wada et al., 1997)

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Of the initial cohort, 102 patients were excluded from the final analysis owing to incomplete questionnaire data or loss to follow-up, yielding a final analytical sample of 114 patients

0.25, 0.5, 1, 2, 4) for 57 days until the matured osteoclasts could be observed in the plates