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519 The activation of this pathway enhances cell proliferation and metastatic capabilities by promoting epithelial-mesenchymal transition (EMT), thereby increasing the invasiveness and metastatic potential of tumors

Avoid too many sugary or caffeinated drinks, as they can dehydrate you

Therefore, the outcomes of extended fasting, particularly in patients with severe obesity, warrant further investigation

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doi:10.1056/NEJMoa2302392 200

In fact, recent phase 3 trial results from late 2025 showed an impressive 28.7% average weight loss at 68 weeks