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Mechanisms of Action and Therapeutic Application of Glucagon-Like Peptide-1

This is particularly interesting for patients with type II diabetes to limit hyperglycemia and the associated deleterious effects of the pathology, but also for obese individuals for weight loss

This led to the identification of GLP-1 as a key player in postprandial glucose regulation

Head-to-head data published in 2024 have not shown significant differences in serious adverse events 6

Coverage is expanding but remains inconsistent

However, caution is recommended in the use of SGLT2i in people with a high risk of amputation or skin ulcers in the lower extremities [89]