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Furthermore, LET7(W372F) carrying the tryptophan-to-phenylalanine substitution W372F and resembling the Hs PP5 hyperactive mutant W386F in the catalytic cleft 33 , exhibited a markedly enhanced PPase activity compared with LET7 (Fig

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MDL29,951 promoted both Gi/o and Gq protein coupling to mediate cyclic AMP (cAMP) and calcium signaling