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Diagnosis of a labial melanocytic macule is primarily clinical, supported by its characteristic appearance

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MOTS-c treatment significantly (i) improves physical performance in young, middle-age, and old mice, (ii) regulates skeletal muscle metabolism and gene expression, and (iii) enhances adaptation to metabolic stress in C2C12 cells in an HSF1-dependent manner

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Bariatric surgery is the most effective treatment in severely obese patients, inducing significant improvement in lobular inflammation and a disappearance of NASH in 5085% of cases (41)

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LE Moore, P Brennan, S Karami, et al

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