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Like many advanced peptides, its a delicate chain of amino acids that can be damaged by improper handling
AstraZenecas Synagis (palivizumab), Amgens Enbrel (etanercept), and Roches Herceptin (trastuzumab) all faced biosimilar entry timelines substantially longer than their basic patent terms would have suggested
Average weight loss in the first month is 3-5 pounds, driven mainly by reduced calorie intake rather than metabolic change
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Another possibility is the existence of differences in the effect of high molecular weight versus low molecular weight peptides on GLP-1R signaling in the CNS [23]
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