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While retatrutide shows lower potency at human GLP-1 and glucagon receptors compared to natural ligands, it demonstrates higher potency at the GIP receptor by a factor of nearly 9x, and the combined effect is what drives the superior outcomes

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Another drug, ES2, targets FOXO4 conserved region 3 (CR3) but has a significantly lower selectivity than FOXO4-DRI 25

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