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However, I think our study is another in a line of already quite a few that seem to indicate that GLP-1 agonists might be helpful in the treatment of alcohol use disorder

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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide

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Layered onto semaglutide's slowing of gastric motility and its effect on visceral sensitivity, the post says this can intensify bile reflux gastritis, a condition it describes as already common after that surgery

Nagata Y, Kanasaki A, Tamaru S, Tanaka K