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Although providers can prescribe medications for off-label use, insurance coverage for a specific indication ideally means patients can afford and access the medication and that sufficient evidence supports its use for that indication

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Dual agonists such as tirzepatide activate both GLP-1 and GIP receptors, adding effects on insulin dynamics and fat metabolism

Nature communications 6, 6498 (2015)

If gastrointestinal side effects prevent escalation at a scheduled step, the current dose should be maintained for an additional four weeks before attempting to increase