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Nature Neuroscience, 27 (3), 433448

The cells do not need constant stimulation, they need periodic reactivation

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Research suggests that NNMT inhibition may influence metabolic pathways related to energy expenditure, fat metabolism, and cellular vitality

doi:10.1002/ptr.7395

The flexibility of the PPP allows macrophages to adapt their metabolism to different functional states, such as pro-inflammatory or anti-inflammatory conditions (Kuchel et al., 1990