doi: 10.1016/j.cgh.2019.12.032 Summary Keywords ulcerative colitis, mitochondria, immune infiltration, metabolism, bioinformatics analysis, machine learning, unsupervised clustering Citation Zhang Y, Fan M, Bai Q, Zhao R, Song S, Wu L, Lu J, Liu J, Wang Q, Li Y and Chen X (2024) Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironment
No hepatotoxicity, nephrotoxicity, or cardiovascular adverse events have been reported in clinical or preclinical studies
We propose a model wherein SYK upregulation serves as a compensatory mechanism that bolsters SC metabolic capacity, fulfilling a dual role: (1) it promotes SC survival by maintaining bioenergetic homeostasis and mitigating mitochondrial damage under stress, thereby preventing glial apoptosis
It is interesting that, same as P2Y12 blockers, Ticagrelor and Clopidogrel have the opposite role in ER stress and eNOS phosphorylation
To be fair pyruvate seems like it would be a bitch to flavor
Adaptation in the form of optimal folate-related gene epistasis and skin pigmentation would be selected to maintain provision of folate coenzymes for crucial methylation and DNA-thymidylate biosynthetic processes
