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Precision prevention and treatment approaches are specifically designed to address the issue of molecular and clinical heterogeneity by identifying a persons specific pattern of risk factors and/or underlying pathophysiologic processes and selecting a preventive or therapeutic intervention strategy that is likely to provide benefit

[1] The gastrointestinal side effects of tirzepatide, particularly nausea, vomiting, and diarrhea, can sometimes be accompanied by systemic symptoms such as weakness, lightheadedness, or body discomfort

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The economic burden is considerable: annual direct healthcare costs attributable to MASLD in the United States and Europe are estimated in the tens of billions of dollars, driven by hospitalizations, liver-related procedures, and management of comorbid conditions [6]

However, it is crucial to acknowledge the potential side effects of these therapies, including gastrointestinal issues, pancreatitis, and the risk of pulmonary aspiration during anaesthesia

More recently, GLP-1 RA drugs have been approved for weight loss, cardiovascular disease, and chronic kidney disease