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In clinical settings, the addition of GIP is thought to make the medication more tolerable for some individuals compared to pure GLP-1 agonists

Xin S, Schick JA

4.2.3 TIMP2 TIMP2 holds a significant role within the family of tissue inhibitors of metalloproteinases, is highly expressed in the myocardium, and its deficiency results in exacerbate ventricular remodeling leading to severe HF (79)