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At the start of 2026, Blue Cross Blue Shield of Massachusetts dropped coverage of GLP-1s for obesity treatment for employers with fewer than 100 employees
Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)
Olesen Synthesis/1949 Laboratoriechef Pharma, Kosmetik & Helse, Biofac/1948 Senior Safety Manager Global Clinical Lead, Clinical Development, Migraine & Pain Medical Writer responsible for Clinical Disclosure You need to be a subscriber to read the rest of the article
However, diabetic patients with concomitant sporadic medullary thyroid carcinomas that express GLP1R in 2030% should probably be excluded from any incretin treatment for their diabetes
However, many people experience a significant reduction in appetite within 1-4 weeks
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