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The comparison with retatrutide is numerically striking but requires careful framing
There was a decrease in 3-methylhistidine (ratio: 0.6)
By starting low and going slow, patients can often avoid these unpleasant reactions, or at least experience them in a milder form
Interestingly, the SURMOUNT-5 trial found that gastrointestinal adverse events causing treatment discontinuation occurred in 5.6% of semaglutide users compared to only 2.7% of tirzepatide users
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