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A study in the International Journal of Obesity found that 60 weeks of treatment led to an average of more than 9% loss in body weight for those taking 192 mg of topiramate daily

One important thing to know is that the GLP-1 medication doesnt permanently fix your appetite

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Therefore, conducting studies under thermoneutral conditions may provide a way to evaluate treatment effects in CNS GIPR KO mice independently of body weight defence mechanisms and temperature-associated thermogenesis

These effects have been attributed to improvements in insulin sensitivity, modulation of lipid metabolism, and activation of enteroendocrine and thermogenic gene programs