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It's the difference between functional and non-functional research material

Comparison with structures of the AMY 1 R bound to non-lipidated peptides (CagriBB and rAmy) revealed that the lipid conjugation does not affect the conformation of the peptide, nor the receptor when Cagri is stably engaged

It does not cause large increases in cortisol or prolactin, and it produces minimal hunger boost compared to GHRP-6

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By activating amylin receptors in the brain, it influences satiety pathways and energy intake control