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The cost of that breadth is that it leans on mechanism and individual trials rather than a single combination headline

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While several E3 ligases were found in complex with NHR-49::GFP in vivo under fasted conditions 42 , we chose the top two interactors to screen: the WW domain-containing E3 ligase, WWP-1, and HECT domain E3 ligase, HECD-1