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Factors that may increase susceptibility to vomiting include rapid dose escalation, consuming large or high-fat meals, pre-existing gastroparesis or other motility disorders, and concurrent use of other medications that affect gastric emptying (such as opioids, anticholinergics, or other GLP-1/GIP agents)

J., Sheehan, S

It remains unclear however, whether this is due to weight loss or other effects of the drugs

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If future clinical evidence supports efficacy in endometriosis, these therapies could move from a partially reimbursed category, often tied to obesity thresholds, into the core of chronic disease management