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An invited review in the New England Journal of Medicine stated it plainly: the positive cardiac and renal effects of GLP-1 receptor agonists are more than just improvement in ambient glucose concentrations, pointing to pleiotropic vascular actions as key contributors to the MACE reductions observed across LEADER, SUSTAIN-6, SELECT, and the other landmark trials

GLP-1 drug claims rose from 6.9% of employer plans in 2023 to 10.5% in 2025, according to Blue Cross Blue Shield data

Immediate next steps: Mark your calendar for your next dose 7 days from the early dose (not 7 days from your original schedule) Monitor for increased nausea or GI symptoms over the next 48 hours If symptoms worsen significantly, contact your provider Resume your normal 7-day schedule from the new injection day What NOT to do: Don't skip your next dose to "make up" for dosing early (this creates a 14-day gap, which is worse than the one-day compression) Don't take your next dose on your original schedule day (this creates a 6-day interval, compounding the problem) Don't adjust your dose down without provider guidance The single early dose is already in your system

(Glucagon-like peptide 1 (GLP-1): physiology, satiety, and metabolism.) Wilding JPH, et al

In the past year, many telehealth and digital health companies, including Hims & Hers competitor Ro, have jumped into the market, offering prescriptions for GLP-1s as part of an existing weight loss or chronic condition management program, or creating a new service line targeting obesity care