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NADPH quantification using iNap1 and iNap3 probes Huh7 and H1299 cells stably expressing iNap1 or iNap3 (FR Biotechnology) were generated by lentiviral infection and puromycin selection

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However, it should not be interpreted as proof of clinical gastrointestinal benefit

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The 100mg cohort showed statistically significant reductions in visceral adipose tissue (8.3% vs baseline) and improvements in insulin sensitivity (HOMA-IR reduction of 18.7%), but no hepatotoxicity signals emerged across any dose tier