As the insulinotropic properties of GLP-1 are retained in patients with diabetes, to test whether activation of hepatic TH signaling has potential therapeutic implications by inducing GLP-1 production, we treated high fat-diet (HFD)-fed mice with MB07811 for two weeks
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Ballatori N, Krance SM, Notenboom S, et al
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Macular OCT revealed atrophy of the ganglion cell layer (GCL) corresponding to the VF defect
Both metanalyses found no evidence of worsening safety risks with combination therapy, although data were limited