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Experts say the approval is a positive step toward managing obesity
For example, in alveolar macrophages, GLP-1 receptor agonism suppressed activation of the NLRP3 inflammasome and reduced production of IL-1 [65], an effect in part mediated by the disruption of histone lactylation, a recognised regulator of pro-fibrotic gene expression [65]
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In coronary heart disease (CHD), accumulation of atherosclerotic plaque in the coronary arteries may prevent parts of the cardiac muscle from getting adequate blood supply, ultimately resulting in heart damage and impaired pumping ability
After 48 weeks: participants lost up to 24.2% of their body weight many people continued losing weight when the study finished researchers suggested weight loss may continue beyond one year substantial reductions in waist circumference were also observed
