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Treatment of mice with oral melatonin (50 or 100 mg/kg) 4 or 8 hours before acetaminophen overdose suppressed the increase in serum ALT and AST activities in a dose- and a time-dependent manner, but had no effect on liver glutathione levels

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Ethanol metabolism plays a significant role in ALD pathogenesis

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Some protocols recommend even lower starting doses around 0.05 mg (50 mcg) for particularly sensitive individuals, though most users find 0.1 mg an appropriate beginning point