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It's this multifaceted potential that makes it such a compelling subject of study

When safety of the study participants and technological developments allow, so called biomarkers can be used to collect PD data to understand if the drug reaches the target, binds to the target and exerts its expected pharmacological activity within the dose range tested

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They also enhance overall quality of life and help prevent long-term medical complications and healthcare burdens

Clinical trial data shows reduced albumin-to-creatinine ratios and no increased risk of adverse renal events, acute kidney injury, or kidney stones

doi: 10.1007/s12020-020-02394-2 116 LovshinJABarnieADeAlmeidaALoganAZinmanBDruckerDJ