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Early treatment with metformin improves neurological outcomes in lafora Disease
In recent years, the number of clinical studies investigating nanoparticle-based therapies for breast cancer has steadily increased (ClinicalTrials.gov, 2025)
Equally, treatment with recombinant human IGF-1 (rhIGF-1) in children with severe IGF-1 deficiency, due to GHR-insensitivity, was shown to increase kidney length [132]
Physical trauma, known as the Koebner phenomenon, can induce the appearance of vitiligo patches in areas of repeated friction, wounds, scars, and pre-existing lesions of contact eczema or psoriasis.76 Exposure to chemicals, such as phenolic derivatives, generates a melanotoxic effect in vitiligo by inducing oxidative stress and causing direct damage to melanocytes
Poor diet: Inadequate consumption of fruits, vegetables, and sulfur-rich foods leads to the reduction of glutathione
