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This timing aligns with natural BDNF rhythms and reduces the likelihood of sleep disruption from its alerting properties

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After an initial loading regimen of 1mg three times weekly for two weeks, maintenance therapy is typically 1mg every three months for life in conditions like pernicious anaemia, or every two months if neurological involvement was present

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People taking high-dose B12 supplements (1,000 to 5,000 mcg daily), receiving B12 injections (cyanocobalamin or methylcobalamin), or consuming heavily fortified foods can easily push their serum levels above 900 pg/mL