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To reconcile the findings that both GIPR antagonists and GIPRAs reduce body weight, it is possible that physiological GIPR activity plays a permissive role in adipose tissue synthesis, while pharmacologically enhanced GIPR activity may reduce body weight through a different mechanism in the brain

Every 10C increase in temperature doubles the degradation rate

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The body stores some B12 in the liver, but excess amounts are flushed out of the body through urine