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Discontinuation, however, may result in a gradual return to the natural skin tone

doi: 10.1042/BST20140016 61 HlscherC

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The thigh is also easy to reach, making it a preferred site for those who self-administer shots

As leukotriene LTA 4 is the precursor of all other leukotrienes as well as being a direct precursor of lipoxins, it has been suggested that as inflammation advances and LTA 4 levels rise, it starts feeding lipoxin synthesis with subsequent initiation of resolution

This is more important with long-lasting drugs like semaglutide or tirzepatide, so the medication clears out of their system