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DOI 10.1007/s00204-026-04499-5.What was investigated: a review of cannabinoid receptor 2 signaling across hepatic lipid metabolism, inflammation, and fibrosis.Apparent findings: the review describes preclinical evidence suggesting cell-specific anti-steatotic, anti-inflammatory, and anti-fibrotic actions of CB2 activation.Limitations and uncertainty: mechanistic and preclinical plausibility does not establish that a CB2-targeting drug safely treats metabolic liver disease in humans.Why noteworthy: it maps an active therapeutic target while showing how much clinical validation remains before treatment claims are justified

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