Researchers should calculate these relationships carefully before establishing their dosing protocol
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For example, GLP-1R in adipocytes can directly regulate apoptosis and preadipocyte proliferation by activating the adenylate cyclase/cyclic adenosine monophosphate (AC/cAMP) signaling pathway and various cell signaling cascades, including extracellular signal-regulated kinase (ERK), protein kinase C (PKC), and protein kinase B (AKT) [41,46]
2 It is possible that lipidation at certain sites can create steric hindrance that does not allow GLP-1Rs to capture ligands directly from the albumin, but only to trap free ligands released by the albumin