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Source: Jastreboff et al., NEJM 2023
Changes to the 2 position group can affect nucleic acid stability and affinity, 227 with common modifications including 2-fluoro (2-F), 2-O-methoxyethyl (2-MOE), and 2-O-methyl (2-OMe)
Several studies have suggested that people with lupus tend to have lower levels of glutathione compared to healthy individuals
An excessive shift in the balance would generate reductive stress leading to the protein aggregates and proteotoxicity as was reported in myocardium (Rajasekaran et al
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