If you do not have severe neurological symptoms, however, research suggests that very high-dose oral supplementation (typically 1,000 mcg daily) can effectively treat B-12 deficiency even in people who have compromised absorption due to lack intrinsic factor (a cause of "pernicious anemia") or from gastrointestinal disease or bowel resection (Lacombe, Am J Clin Nutr 2024
This involves a rigorous review of studies, including those with potential biases favouring the arginine variant and weighing them against independent findings
Additionally, inflammatory conditions are also suggested to benefit due to its regenerative and protective properties
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The blend is convenient when a 1:1 ratio (5mg each) matches the research protocol and the goal is studying the combination effect
Those on a vegan diet naturally eliminate protein sources such as chicken, eggs (the health benefits of eggs are endless and might warrant inclusion in your diet), and fish, which have high amounts of B12