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Discontinuation criteria protect patients from progressive organ damage: AST/ALT exceeding 40 IU/L Bilirubin above 21 mol/L Creatinine surpassing 90 mol/L in females These safety parameters require immediate cessation of therapy to prevent irreversible organ damage

1987 Jan;184(1):113-7

Hypoxia increases mitochondrial ROS formation and leads to enhanced infiltration of activated inflammatory cells (71)

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