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For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation

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High-dose therapies potentially speed up detoxification in people who face significant environmental stressors

Furthermore, 3672% of patients initially diagnosed with SJS/TEN end up having their diagnosis reclassified into a different disease, also contributing to an overestimation of SJS/TEN incidence [13]

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