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From a pharmacological safety perspective, the adverse effect profile of retatrutide based on Phase 1 and Phase 2 clinical trial data (including the NEJM 2023 Phase 2 trial) includes: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (the most commonly reported side effects in trial participants) Injection site reactions: Redness, swelling, or discomfort at the injection site Cardiovascular effects: Increases in heart rate have been observed in trial participants [21] [22] Hypoglycaemia: Particularly relevant in individuals with diabetes or those taking insulin, sulfonylureas, or other glucose-lowering agents Potential thyroid effects: GLP-1 receptor agonists have been associated with thyroid C-cell changes in rodent studies

Lipid signalling enforces functional specialization of T(reg) cells in tumours

Columbia University School of International Affairs: associate professor, 1996-2002

The maximum maintenance dose 25mg has been shown to help patients lose 17% of their starting weight on average

Dulaglutide: Trulicity contains dulaglutide

Everyone's different: Your doctor can help you find the best approach for your individual needs