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However, despite affinity, albeit lower, of tirzepatide for the GLP-1 receptor, tirzepatide had no effect on body weight, food intake, fasting insulin, endogenous glucose production and insulin-stimulated glucose uptake in skeletal muscle and subcutaneous white adipose tissue of GLP-1 receptor knockout mice [89]

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Drug and Alcohol Dependence 98 pp112 Kanayama G, Kean J, Hudson JI, & Pope HG Jr (2013): Cognitive deficits in long-term anabolic-androgenic steroid users

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Dosage and Duration of Use: Someone on a higher maintenance dose who has been on the medication for a year will have a more established steady-state concentration than someone who only took a low starting dose for a few weeks