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New England Journal of Medicine , 387 (3), 205-216

If dietary measures are insufficient, over-the-counter fiber supplements (psyllium, methylcellulose) or osmotic laxatives (polyethylene glycol) may be appropriate after discussing with your healthcare provider

Harkey MA et al

The modified Delphi method was used to establish the strength of each recommendation

If you have arrived here from a search like "what is the best copper peptide" or "best GHK-Cu copper peptide serum brands 2026," here is the direct answer before the nuance: for the majority of users, the best copper peptide is a stable 12% GHK-Cu serum formulated at a mildly acidic pH, packaged to protect the peptide from light and air, and kept relatively simple so the copper complex is not competing with aggressive actives

Flatulence: Avoid gas-causing foods, eat slowly, and walk regularly