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In a series of papers [3436], Ookhtens and colleagues showed that the half-life of glutathione in the liver was quite low, approximately 23 hours, consistent with the result of Lauterburg [47]
We also failed to detect an increase in MitoSOX-sensitive mitochondrial ROS production in erastin-treated RPE cells
The findings are intriguing because they align with what weve seen in preclinical models and some human studies: GLP-1RAs appear to reduce neuroinflammation, improve insulin signaling in the brain, and potentially slow processes associated with cognitive decline, he noted
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