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However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])

Research your destination country's regulations, carry a detailed prescriber's letter, declare the medication at customs, and if you are a clinical trial participant, obtain explicit approval from your trial sponsor before travelling abroad

Scheme 19

Clin Exp Immunol (2001) 126:41220

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It is important to note that most available data reflect relatively short to medium-term exposure (typically under five years)