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Strengths of STEP 5 include the high rates of adherence to treatment and completion of the trial (which contributed to consistency in findings between the two estimands)
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The two strategies are therefore not substitutes, and they have very different evidence profiles
In a study of 10 healthy male volunteers, omeprazole, in doses of 20 mg40 mg per day, caused a significant decrease in the oral absorption of methylcobalamin, vitamin B12
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