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Second, it is able to induce the combination of ,-unsaturated ketones and GSH through the nucleophilic addition reaction, depleting GSH and reducing the amount of GSH available to combine with chemotherapeutic agents, thus producing an overall GST-inhibitory effect by sensitizing a cell to chemotherapeutic agents
Baseline characteristics of the patient population in the Saxagliptin Assessment of Vascular Outcomes Recorded in patients with diabetes mellitus (SAVOR)-TIMI 53 trial
Moreover, through receptor-independent actions, CBD and CBG activate Nrf2, a transcription factor that upregulates antioxidant defenses such as SOD, CAT, and GSH-Px
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But Adam estimates that, for someone carrying two copies, the difference could represent around 10% of their expected weight loss which is, on reflection, significant
